The incidence of Lyme disease is growing, as is its geographical extent. One of the greatest challenges clinicians face is early diagnosis, so effective antibiotic treatment can begin rapidly. Scientists from Colorado, Florida, and New York believe they have located a way to accurately identify Lyme disease from similar illnesses, like southern tick-associated rash illness. They found that the human body reacts differently to these disorders, and the resulting biomarkers can accurately (98%), in the laboratory, differentiate Lyme disease from the others. The next step is to utilize these biomarkers to develop a reliable blood test.